Head of Research Group: Prof. Attila CSIKÁSZ-NAGY
Members of the Group: Bence GAIZER, Tünde Éva GAIZER, Dr. János JUHÁSZ, Valentina MADÁR, Dr. Csaba István PONGOR, Bíborka PILLÉR, Petra SOMOGYVÁRI, János SZALMA, Áron WEBER
Contact: csikasz-nagy.attila@itk.ppke.hu
We investigate the spatio-temporal dynamics of intracellular molecular interactions and intercellular interactions by combining computational systems biology model-ing with experimental methods. By converting molecular networks into mathemati-cal equations, we analyze the physiological behavior of these systems. Our research focuses on the regulation of cell growth and cell division. We collect data in collab-oration with experimental laboratories and test the predictions of our models.
In our own laboratory, we study cell-cell interactions among yeast strains and inte-grate our results with our models to deepen our understanding of intercellular com-munication. In cooperation with research groups within the Faculty, we also devel-op epidemic spread models that can support decision-making in epidemiological emergencies. With our computational systems biology methods, we also uncover the mechanisms of action of drugs, contributing to the development of safer preparations.
Microscopic image and simulation result of a mixed colony of two yeast strains. The image on the left shows the two strains with fluorescent labeling, while on the right, the arrangement of agents, indicated by different colors, was simulated in an agent-based mathematical model.
Future research directions, collaboration opportunities
The research group offers collaboration in experimental projects using yeast, particularly in the areas of cell communication and the ecology of microbial communities, and, from a modeling perspective, on topics such as cell division, growth, signaling, circadian rhythm, and their relationships.
Key publications
- Ecker, A. , Szabó, G., Szalma, J., Fichó, E., Reguly, I., & Csikász-Nagy, A. (2026). Digital twin ap-proaches for interpretable side effect prediction in drug discovery. DRUG DISCOVERY TODAY, 104637.
- Gaizer, T., Juhász, , Pillér, B., Szakadáti, H., Pongor, C. I., & Csikász-Nagy, A. (2024). Integrative analysis of yeast colony growth. COMMUNICATIONS BIOLOGY, 7 .1, 511.
- Chakravarty, S., Hong, C.I., and Csikász-Nagy. (2023). Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadi-an rhythms. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 9.1, 5.
