Tantárgy adatlapja
1.Morphological/cellular characteristics of the physiological barriers
2. Molecular characteristics of the physiological barriers
3. Drug delivery accross the physiological barriers
4. Methodological opportunities for testing drug delivery accross the barriers
5.Microfluidic diffusion chambers in drug delivery studies
6.Chemical enhancers of drug delivery
7.Physical enhancers of drug delivery
8.Drug formulations to assisst drug delivery
9.Studying species differences in the skin
10. How to consider the 3R rules in drug delivery studies
11.Physiological barriers in health and disease.
12.Mathematical simulation of drug penetration
List of selected literature:
Erdo, Franciska ; Bors, Luca Anna ; Farkas, Dániel ; Bajza, Ágnes ; Gizurarson, Sveinbjörn, Evaluation of intranasal delivery route of drug administration for brain targeting, BRAIN RESEARCH BULLETIN 143 pp. 155-170. , 16 p. (2018) Erdo, F ; Denes, L ; de Lange, E, Age-associated physiological and pathological changes at the blood-brain barrier: A review. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 37 : 1 pp. 4-24. , 21 p. (2017) Ponmozhi J, Dhinakaran S, Kocsis D, Iván K, Erdo F.Models for barrier understanding in health and disease in lab-on-a-chips. TISSUE BARRIERS. 2023 Jun 9:2221632. doi: 10.1080/21688370.2023.2221632 Kocsis D, Kichou H, Döme K, Varga-Medveczky Z, Révész Z, Antal I, Erdo F. Structural and Functional Analysis of Excised Skins and Human Reconstructed Epidermis with Confocal Raman Spectroscopy and in Microfluidic Diffusion Chambers. Pharmaceutics. 2022 Aug 13;14(8):1689. doi: 10.3390/pharmaceutics14081689. Kocsis D, Klang V, Schweiger EM, Varga-Medveczky Z, Mihály A, Pongor C, Révész Z, Somogyi Z, Erdo F. Characterization and ex vivo evaluation of excised skin samples as substitutes for human dermal barrier in pharmaceutical and dermatological studies. Skin Res Technol. 2022 Jun 21. doi: 10.1111/srt.13165Share Luca Anna Bors and Franciska Erdo Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery, Sci. Pharm. 2019, 87(1), 6; https://doi.org/10.3390/scipharm87010006 List of required competences: Analysing and synthetizing ability to make short, informative presentations on recent scientific results on drug delivery research across the physiological barriers.Getting theoretical background knowledge on the field of physiological barriers and making and evaluating drug delivery experiments.
