Tantárgy adatlapja
The subject introduces some key concepts and facts regarding the roles and mechanisms of biochemical signaling in nerve cells. The focus of the course is on neurotransmitter receptors and intracellular signaling pathways that are critical for synaptic transmission and plasticity. The main topics of the course are the following:
- Neurochemical examination and analysis methods
- Presynaptic mechanisms of synaptic transmission
- Ionotropic receptors
- Metabotropic receptors
- Neurotransmitter co-transmission
- Retrograde neurotransmission
- Plasticity-related actions of protein kinases and phosphatases
- Interactions between ion channels and intracellular signaling pathways
- Intracellular mechanisms of spike-timing-dependent plasticity
- Neural activity-dependent regulation of gene expression
11. Structural plasticity
List of selected publications:
> Z. Wu, D. Lin, and Y. Li, ’Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators’, Nature Reviews Neuroscience, vol. 23, no. 5, Art. no. 5, May 2022, doi: 10.1038/s41583-022-00577-6. List of required competences: a) Knowledge - Understanding - the basic experimental/examination approaches used to collect biochemical data from neurons for research, diagnostic and therapeutic purposes - the main molecular mechanisms involved in synaptic transmission and plasticity - the pathological changes in the operation of synapses and the employed diagnostic/therapeutic approaches b) Skills - reviewing the literature and giving short presentations from selected topics
